The Best of Two Worlds in App-V - Brian Madden (blog)

Application publication still happens from the main site dedicated server, but application use is not recorded and no reporting or licensing is available (but this removes the Sql dependency). An Unexpected Question With the client in stand-alone mode for use with virtual application MSIs, or with clients configured for SCCM you do not configure the App-V client to talk to a publishing server. In fact, Microsoft made it very clear when they released the MSI tool last year that once you configure the client to work with MSIs it will only work with MSIs. We were testing with the MSI client in the class last week when Christopher Cawvey asked what would happen if we did configure the client to talk to the publishing server. But I figured that maybe we could use the MSI with no start menu or desktop shortcuts, to add the virtual application and fill the cache, then try to use the dedicated server to perform per-user application publishing. In one case, we publish the virtual applciation without shortcuts via SCCM R2. In the other case, we install the virtual applciaiton on the client using the MSI (which could have been pushed out using any version of SCCM, or SMS, or another ESD... Source: www.brianmadden.com